The oxytocin receptor gene in social belonging processes in adolescents; an exploratory study

The oxytocin receptor gene in social belonging processes in adolescents; an exploratory study - OXTR gene and social belonging in adolescents

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40884

Enrollment

1000

Registered

2014-02-25

Start date

2014-02-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

niet op aandoening, maar op sociaal emotionele uitkomsten (geen stoornissen) emotion recognition social emotional processes

Interventions

None listed

Eligibility

Age

12 Years to 17 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet the following criteria: - Being in 2nd grade of high school, - Being of white European descent (subjects of other ethnic origins are able to participate, but do not have to provide saliva for DNA analyses).

Exclusion criteria

Exclusion criteria: There are no exclusion criteria other than having impaired vision or blindness. In this case, adolescents cannot conduct the (micro-expression) computer task.

Design outcomes

Primary

Measure	Time frame
The main study parameter of the computer task on micro-expression is emotion recognition (the amount of correctly identified emotions within each emotion; anger, fear, sadness and happiness). This will be a proportion measure (i.e., the amount of correctly identified emotions divided by the total amount of that specific emotion). The main study parameters of the eye tracking experiment are total gazing times and gazing time per event to different areas of interest (AOI). A gaze fixation will be defined as gazing at a specific region for 100 ms or longer. More specific, total gazing time (total fixation duration) is the total time a participant gazes at a specific AOI stimulus in ms. Gazing time per event (mean fixation duration) is the average duration of each fixation within a specific AOI of a single stimulus. Other endpoints are loneliness, depression, social anxiety, and satisfaction with relationships (based on questionnaire data).	—

Measure

Time frame

The main study parameter of the computer task on micro-expression is emotion recognition (the amount of correctly identified emotions within each emotion; anger, fear, sadness and happiness). This will be a proportion measure (i.e., the amount of correctly identified emotions divided by the total amount of that specific emotion). The main study parameters of the eye tracking experiment are total gazing times and gazing time per event to different areas of interest (AOI). A gaze fixation will be defined as gazing at a specific region for 100 ms or longer. More specific, total gazing time (total fixation duration) is the total time a participant gazes at a specific AOI stimulus in ms. Gazing time per event (mean fixation duration) is the average duration of each fixation within a specific AOI of a single stimulus. Other endpoints are loneliness, depression, social anxiety, and satisfaction with relationships (based on questionnaire data).

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Secondary

Measure	Time frame
Genetic Material. To assess the role of variation in the OXTR gene, saliva samples will be collected by means of saliva containers following standardized procedures (Oragene, DNA Genotek Inc). Several polymorphisms (a.o. rs53576, rs2254298, rs237885) within the OXTR gene will be genotyped at the reserachlab. These will be dummy-coded into 1 (carrier of one or two minor alleles) and 2 (homozygote for the major allele).	—

Measure

Time frame

Genetic Material. To assess the role of variation in the OXTR gene, saliva samples will be collected by means of saliva containers following standardized procedures (Oragene, DNA Genotek Inc). Several polymorphisms (a.o. rs53576, rs2254298, rs237885) within the OXTR gene will be genotyped at the reserachlab. These will be dummy-coded into 1 (carrier of one or two minor alleles) and 2 (homozygote for the major allele).

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Countries

Netherlands

Outcome results