Quantification of Parkinson*s Disease motor symptoms using the PowerGlove

Quantification of Parkinson*s Disease motor symptoms using the PowerGlove - iDBS-PowerGlove

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40878

Enrollment

Registered

2014-08-21

Start date

2014-10-14

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease PD

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - The patient has had Parkinson's symptoms for more than five years. - The patient has a good response to dopaminergic medication. - The patient is selected to undergo preoperative screening for Parkinson DBS surgery in the Academic Medical Center, Amsterdam. - The patient is able to communicate adequately in Dutch or English. - The patient is between the age of 18 and 80.

Exclusion criteria

Exclusion criteria: - The patient has a medical (or other) history other than Parkinson's disease which restricts hand movement (e.g. a complicated wrist fracture of severe arthritis). - Inability to correctly place the PowerGlove on the patient's hand or to correctly perform the necessary calibration.

Design outcomes

Primary

Measure	Time frame
The primary study parameters in this study are the sensitivity, specificity and reliability of the PowerGlove system in measuring the Parkinson symptoms rigidity, bradykinesia and tremor. These are derived from the relations between: - moment of force and range of motion generated in passive wrist flexion, measured by the PowerGlove system, - speed and amplitude of hand and finger kinematics in different active hand movement tasks, measured by the PowerGlove system, - frequency characteristics and amplitude of hand movement in rest, measured by the PowerGlove system, and - UPDRS scores for rigidity, bradykinesia and tremor, assessed by an experienced clinician (UPDRS part III, items 20-25) in different points over time, ON- and OFF-medication, and executed by different experienced clinicians.	—

Measure

Time frame

The primary study parameters in this study are the sensitivity, specificity and reliability of the PowerGlove system in measuring the Parkinson symptoms rigidity, bradykinesia and tremor. These are derived from the relations between: - moment of force and range of motion generated in passive wrist flexion, measured by the PowerGlove system, - speed and amplitude of hand and finger kinematics in different active hand movement tasks, measured by the PowerGlove system, - frequency characteristics and amplitude of hand movement in rest, measured by the PowerGlove system, and - UPDRS scores for rigidity, bradykinesia and tremor, assessed by an experienced clinician (UPDRS part III, items 20-25) in different points over time, ON- and OFF-medication, and executed by different experienced clinicians.

—

Secondary

Measure	Time frame
Secondary study parameters of interest are: - EMG activity recorded during passive wrist flexion. - Gender - Age - Disease duration - Medication use - Dominant left of right hand - Body weight - Body length - Hand size	—

Countries

Netherlands

Outcome results