effecten van stress op MRS metabolieten bij jeugdtrauma Childhood-trauma associated psychiatric disorders
Conditions
Interventions
Stress test or a control test randomized.
o Stress: the Trier Social Stress Test (TSST), an validated and standardized
test to induce psychosocial stress in laboratory settings.
o Control: a validate
Sponsors
Psychiatrie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Male sex - Age between 18 and 40 years old - Either low or high levels of childhood maltreatment
Exclusion criteria
Exclusion criteria: General exclusion criteria: - Incapability of giving informed consent - Lack of fluency in the Dutch language or speech impairments - Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel). - Use of medication which might influence the stress response, such as psychotropics, beta blockers, ACE inhibitors and any hormonal treatment. - Major medical history including history of closed or open head injury. - Acute minor medical illness within the three weeks prior to testing - History of any psychiatric, neurological or endocrine disorder including claustrophobia and alcohol abuse or dependence - Self-reported current smoking in the last 2 weeks - Self-reported current or past drug use in the last 2 weeks - Ferrous objects in or around the body according to default checklist present at 7T scanner (version defined by METC protocol 07-235: *MRI development for 7T (and lower field strengths)* ;Acute exclusion criteria on 2nd and 3rd visit: - Any acute inflammatory disease - Physical exertion within the last 2 hours - Drink other than water or any food within the last 2 hours - Any alcohol use in the last 24 hours - Positive urine screen on the presence of amphetamines (including MDMA), barbiturates, cannabinoids, benzodiazepines, cocaine and opiates)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary parameter: Concentrations of glutamate, glutamine, GABA, choline, NAA, creatine, myoinositol and lactate as measured by 7T-MRS. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters: - Basal and stress-induced levels of cortisol, alpha amylase, and heart rate. - Perceived stress levels. - (Epi)genetic variation in a limited number of stress genes. - Plasma GABA levels | — |
Countries
Netherlands
Outcome results
None listed