Troponin Activator to Restore Diaphragm Function in COPD

Troponin Activator to Restore Diaphragm Function in COPD - troponin activator and COPD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40872

Enrollment

Registered

2014-12-17

Start date

2015-01-15

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diaphragm weakness in COPD

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Patients with COPD scheduled for a thoracotomy for resection of a small pulmonary tumor. -Patients with normal lung function scheduled for a thoracotomy for resection of a small pulmonary tumor. (These patients will serve as controls). -Age: >18 years -Gender: both male and female -all ethnic backgrounds

Exclusion criteria

Exclusion criteria: -CHF (NYHA class III-IV) -Neuromuscular disease -Drugs known to alter muscle structure and function -Chronic metabolic disease -Pulmonary hypertension -Chronic use of corticosteroids (defined as >7.5 mg/day for at least 3 months) ->10% weight loss within last 6 months.

Design outcomes

Primary

Measure	Time frame
* contractile force of single diaphragm muscle fibers	—

Secondary

Measure	Time frame
* contractile force of single latissimus dorsi muscle fibers	—

Countries

Netherlands

Outcome results