Depression Major depressive disorder
Conditions
Interventions
All 24 participants will experience the rTMS treatment. Once real rTMS and once
sham-rTMS, both will take 30 minutes. The two intervention sessions will be
separated by at least 1 week with a maximu
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 24 healthy, right-handed women using oral contraceptives and men (aged 18-35) with normal or corrected-to-normal vision
Exclusion criteria
Exclusion criteria: * Epilepsy, convulsion or seizure (TMS) * Serious head trauma or brain surgery * Large or ferromagnetic metal parts in the head (except for a dental wire) * Implanted cardiac pacemaker or neurostimulator * Pregnancy * History or current presence of any neurologic or psychiatric disease * Any prescribed medication that can alter cortical excitability (e.g. antiepileptics, tricyclic anti-depressives or benzodiazepines) or can have an influence on the participant*s vigilance or cognitive performance within two weeks prior to participation * Color blind
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate the effect of rTMS and sham rTMS on mood as measured with changes in visual analogue scales and PANAS before and after negative mood induction. | — |
Secondary
| Measure | Time frame |
|---|---|
| To investigate the effect of rTMS and sham rTMS on motivated attention for sad and facial expressions after sad mood induction. | — |
Countries
Netherlands
Outcome results
None listed