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Intestinal microvascular alterations and cytokine kinetics following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy

Intestinal microvascular alterations and cytokine kinetics following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy - MACH-study

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON40837
Enrollment
15
Registered
2014-08-06
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastrointestinal micorcirculation gastrointestinal microvascularisation

Interventions

None listed

Sponsors

Sint Antonius Ziekenhuis
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Patients > 18 years of age In order to be eligible to participate in this study, a subject must meet all of the following criteria: Undergoing a CS-HIPEC procedure for colorectal carcinoma Chemotherapeutic agent used for HIPEC is Mitomycin-C Signed informed consent

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: * Age

Design outcomes

Primary

MeasureTime frame
To describe gastrointestinal microcirculation and cytokine kinetics (CRP, white blood cell, IL-6, IL-8, IL 10 and TNF-* levels) in blood samples during and after CS-HIPEC procedure.—

Secondary

MeasureTime frame
Body (core) temperature, Cardiac output (CO), Stroke volume (SV), Stroke Volume Variation (SVV), these later parameters are automatically measured by the flow-trac/vigileo and thus only accesable when an arterial catherter is inserted.—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)