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Blood Pressure and Cardiac Output - the influence on cerebral perfusion during cardiopulmonary bypass.

Blood Pressure and Cardiac Output - the influence on cerebral perfusion during cardiopulmonary bypass. - Parameters of cerebral perfusion

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON40836
Enrollment
32
Registered
2014-07-30
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patienten aan de cardiopulmonale bypass cerebral autoregulation oxygen regulation of the brain

Interventions

5 interventions which will include raising mean arterial pressure (MAP) by administering 100µg phenylephrine, increasing and decreasing cardiac output by adjusting roller pump flow or a combination

Sponsors

Universitair Medisch Centrum Utrecht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - age over 18 years - undergoing cardiopulmonary bypass for Coronary Artery Bypass Grafting (CABG)/Valve replacement/repair - having an appropriate temporal bone window for TransCranial Doppler monitoring

Exclusion criteria

Exclusion criteria: - requiring hypothermia during surgery - requiring emergency surgery - having a contraindication for phenylephrine - having known brain pathology (e.g. Cerebral Vascular Accident (CVA) of increased intracranial pressure) - having a history of severe carotid artery stenosis

Design outcomes

Primary

MeasureTime frame
Primary endpoint is the cerebral perfusion measured by the regional cerebral oxygen saturation (rSO2) and the mean velocity of bloodflow in the middle cerebral artery (Vmca).—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)