gut peptide GLP-1 sugar disease
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - 10 Male healthy volunteers of South Asian descent and 10 male healthy volunteers of western- european descent, born in the Netherlands - Age > 18 years and * 25 years - BMI > 20 kg/m2 and
Exclusion criteria
Exclusion criteria: - A first degree (parent or sibling) relative with T2D - Diabetes mellitus as defined by ADA criteria{2014 12 /id} - Any significant chronic disease - Renal, hepatic or endocrine disease - Clinical cardiovascular disease, including complaints of angina pectoris or intermittend claudicatio - Smoking - Use of medication known to influence glucose and/or lipid metabolism - Recent weight changes or attempts to loose weight (> 3 kg weight gain or loss, within the last 3 months) - Difficulties to insert an intravenous catheter - Recent blood donation (within the last 3 months) - Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - AUC GLP-1 in SA versus WE - peak GLP-1 level in SA versus WE - time to peak GLP-1 in SA versus WE - iinsulin sensitivity by Matsuda-index in SA versus WE | — |
Secondary
| Measure | Time frame |
|---|---|
| - does peak GLP-1 in plasma precede the peak of plasma insulin? - insulin sensitivity by Matsuda-index in SA versus WE - is metabolic flexibility in SA impaired (switch from glucose to lipid metabolism and vice versa) | — |
Countries
Netherlands
Outcome results
None listed