THORACIC FLUID ASSESSMENT BY DYNAMIC CONTRAST-ENHANCED MRI AND BIOIMPEDANCE SPECTROSCOPY: AN EXPLORATIVE STUDY IN HEALTHY SUBJECTS

THORACIC FLUID ASSESSMENT BY DYNAMIC CONTRAST-ENHANCED MRI AND BIOIMPEDANCE SPECTROSCOPY: AN EXPLORATIVE STUDY IN HEALTHY SUBJECTS - Extravascular lungwater assessment by CeMR and BIS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40803

Enrollment

Registered

2014-10-31

Start date

2015-03-11

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intrathoracic bloodvolume

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Age >18 years • Informed consent. • Body mass index between 18 and 25

Exclusion criteria

Exclusion criteria: • end-stage renal or hepatic disease • pregnancy • mild or moderate renal insufficiency, (GFR

Design outcomes

Primary

Measure	Time frame
A. To optimize the DCE-MRI sequence parameters and to evaluate a reference values for indicator dilution curves derived parameters in healthy volunteers B. To evaluate whether bolus kinetic derived DCE-MRI parameters can track changes in response to fluid challenge/auto-transfusion in healthy volunteers C. To evaluate the agreement between changes in bolus kinetic parameters measured by DCE-MRI and changes in impedance measured by bio-impedance spectroscopy	—

Measure

Time frame

A. To optimize the DCE-MRI sequence parameters and to evaluate a reference values for indicator dilution curves derived parameters in healthy volunteers B. To evaluate whether bolus kinetic derived DCE-MRI parameters can track changes in response to fluid challenge/auto-transfusion in healthy volunteers C. To evaluate the agreement between changes in bolus kinetic parameters measured by DCE-MRI and changes in impedance measured by bio-impedance spectroscopy

—

Secondary

Measure	Time frame
A. To evaluate the relationship between bolus kinetic parameters and RV and LV functional parameters. B. To evaluate reproducibility of MR based bolus kinetic parameters measurement and to evaluate sensitivity to MR sequence parameters.	—

Countries

Netherlands

Outcome results