The long term effects of coal tar treatment on the microbiome and DNA methylome in atopic dermatitis skin.

The long term effects of coal tar treatment on the microbiome and DNA methylome in atopic dermatitis skin. - Long term effects of coal tar on eczema skin.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40800

Enrollment

Registered

2014-12-08

Start date

2015-06-22

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopic dermatitis eczema

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with: Atopic dermatitis

Exclusion criteria

Exclusion criteria: pregnancy in first trimester

Design outcomes

Primary

Measure	Time frame
The outcome of the study A and B is a nearly complete skin microbiome of each of the samples. Analysis of the taxonomic units will allow us to correlate the presence or absence of certain taxa with coal tar treatment of normal and eczema skin. This study is expected to generate hypotheses that can be tested subsequently in larger groups using a more focused and less expensive approach. The outcome of study C is a methylome analysis of a limited number of patients before and after coal tar treatment. Only when gross changes are observed, a controlled follow-up study will be initiated.	—

Measure

Time frame

The outcome of the study A and B is a nearly complete skin microbiome of each of the samples. Analysis of the taxonomic units will allow us to correlate the presence or absence of certain taxa with coal tar treatment of normal and eczema skin. This study is expected to generate hypotheses that can be tested subsequently in larger groups using a more focused and less expensive approach. The outcome of study C is a methylome analysis of a limited number of patients before and after coal tar treatment. Only when gross changes are observed, a controlled follow-up study will be initiated.

—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results