Assessment of blood flow velocity and oximetry using non-invasive retinal and cutaneous microcirculation imaging in sickle cell disease (SCD) patients and healthy volunteers.

Assessment of blood flow velocity and oximetry using non-invasive retinal and cutaneous microcirculation imaging in sickle cell disease (SCD) patients and healthy volunteers. - Measurements of bloodflow in sickle cell patients and healthy volunteers.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40787

Enrollment

Registered

2014-10-02

Start date

2014-10-13

Completion date

Unknown

Last updated

2024-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sickle cell anaemia Sickle cell disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria Sickle cell disease patients 1. Male or female subjects, 18-65 years of age, inclusive; 2. Moderate to severe SCD with a history of at least 4 vaso-occlusive crises in total and at least 1 vaso-occlusive crisis in the last 12 months;;Healthy volunteers 1. Healthy subjects, as defined by the absence of evidence of any active or chronic disease following a medical and surgical history, a physical examination including vital signs. 2. Matched to sickle cell disease patients for gender, age (± 5 years), ethnicity, smoking behavior and body mass index (±3 kg/m2).

Exclusion criteria

Exclusion criteria: Sickle cell disease patients 1. History or symptoms of any significant disease including (but not limited to), neurological, psychiatric, endocrine, cardiovascular, respiratory, gastrointestinal, hepatic, or renal disorder, excluding SCD and conditions that are related to SCD. 2. Recent occurrence (

Design outcomes

Primary

Measure	Time frame
Retinal blood flow by NiRFI: - blood flow velocity - capillary perfusion maps and microvasculature enhancement - blood oximetry - metabolic intrinsic state/function Cutaneous microvascular blood flow by LSCI: - basal blood flow - flow upon occlusion-reperfusion - blood flow upon inspiratory breath holding	—

Countries

Netherlands

Outcome results