effecten van sympathicusblokkade door epidurale anesthesie met algehele anesthesie epidural puncture Thoracic epidural anesthesia
Conditions
Interventions
Noradrenalin infusion is started 30 minutes after induction of TEA. The
measurements are performed 15 minutes after noradrenalin infusion is started.
Noradrenalin infusion is stopped and baseline me
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All adult patients scheduled for lung surgery under thoracic epidural and general anaesthesia
Exclusion criteria
Exclusion criteria: * Participation in a trial on investigational drugs within 3 months prior to the study * Hemodynamic instability prior to start of measurements with the systolic blood pressure decreasing more than 30% below the pre-anaesthetic value or a mean arterial pressure (MAP) 18 mm Hg and/ or a cardiac index
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objectives of this study consist of: - To evaluate the effects of thoracic epidural anaesthesia (TEA) under general anaesthesia on mean systemic filling pressures, arterial- and venous resistance and cardiac output. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives consist of: - To assess the hemodynamic effects of vasopressors and fluid loading under TEA with general anaesthesia conditions - To assess the value of stroke volume variation and pulse pressure variation,to predict fluid loading responsiveness with TEA. | — |
Countries
Netherlands
Outcome results
None listed