Identification of potential pathogens responsible for influenza-like illness in elderly in The Netherlands. Evaluation of humoral and cellular immunity against identified microorganisms

Identification of potential pathogens responsible for influenza-like illness in elderly in The Netherlands. Evaluation of humoral and cellular immunity against identified microorganisms - ILI in elderly - GRIEP-3

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40776

Enrollment

2500

Registered

2014-07-04

Start date

2014-07-15

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

flu influenza

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * * 60 years of age * Willing to present when ILI symptoms occur * Signed Informed Consent

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
Primary: presence of influenza virus in nasopharyngeal and oropharyngeal swab during ILI episodes	—

Secondary

Measure	Time frame
Secondary: influenza virus subtypes in case of influenza infection Secondary: antibody levels to influenza virus and activation of T cells after influenza infection (humoral and cellular immune responses) Secondary: presence of viruses (other than influenza) in nasopharyngeal and oropharyngeal swabs collected in subjects reporting with ILI during ILI episodes, 2-3 weeks later and 7-9 weeks later, and additionally at two time points with a 2-3 week interval in a subset of participants without having had ILI Secondary: presence of bacterial microorganisms in nasopharyngeal and oropharyngeal swabs collected in subjects reporting with ILI during ILI episodes, 2-3 weeks later and 7-9 weeks later after, and additionally at two time points with an interval of 2-3 weeks in a subset of participants without having had ILI Secondary: humoral and cellular immune responses against potential pathogens identified in PCR/culture data Secondary: presence of S. pneumoniae in saliva Secondary: a SF-36 (short-form health survey) questionnaire and vaccine acceptance at the start of the season, i.e. after signing of Informed Consent Exploratory: humoral and cellular immune responses against herpes viruses Exploratory: profile of the intestinal microbiome	—

Measure

Time frame

Secondary: influenza virus subtypes in case of influenza infection Secondary: antibody levels to influenza virus and activation of T cells after influenza infection (humoral and cellular immune responses) Secondary: presence of viruses (other than influenza) in nasopharyngeal and oropharyngeal swabs collected in subjects reporting with ILI during ILI episodes, 2-3 weeks later and 7-9 weeks later, and additionally at two time points with a 2-3 week interval in a subset of participants without having had ILI Secondary: presence of bacterial microorganisms in nasopharyngeal and oropharyngeal swabs collected in subjects reporting with ILI during ILI episodes, 2-3 weeks later and 7-9 weeks later after, and additionally at two time points with an interval of 2-3 weeks in a subset of participants without having had ILI Secondary: humoral and cellular immune responses against potential pathogens identified in PCR/culture data Secondary: presence of S. pneumoniae in saliva Secondary: a SF-36 (short-form health survey) questionnaire and vaccine acceptance at the start of the season, i.e. after signing of Informed Consent Exploratory: humoral and cellular immune responses against herpes viruses Exploratory: profile of the intestinal microbiome

—

Countries

Netherlands

Outcome results