The effect of neuromuscular electrical stimulation on post-prandial protein accretion during the day and prior to sleep

The effect of neuromuscular electrical stimulation on post-prandial protein accretion during the day and prior to sleep - ES-PRO comparison

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON40767

Enrollment

Registered

2014-12-18

Start date

2015-01-23

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

loss of muscle mass Sarcopenia

Interventions

Consumption of a bolus of intrinsically L[13C]phenylalanine labelled casein protein and 70 min of one-legged NMES, either during the day or prior to sleep.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age 65-85 years - Male - 18.5 * BMI * 30.0

Exclusion criteria

Exclusion criteria: - Type II diabetes - All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery). - Use of anticoagulants, blood diseases, allergy for lidocain - Use of NSAIDs and acetylsalicylic acid - Patients suffering from PKU (Phenylketonuria) - Presence of implantable cardioverter defibrillator and/or pacemaker - Performed regular resistance type exercise in the past 6 months - Use of any tools to assist during walking (cane/ crutches/ walker) - (Partial) foot/ leg amputation

Design outcomes

Primary

Measure	Time frame
De novo muscle protein accretion, measured as enriched muscle protein [mole percent excess (MPE)].	—

Secondary

Measure	Time frame
Plasma amino acid enrichment after ingestion of the intrinsically labeled protein	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)