Visualization of nerves and muscles in the forearm - In patients with multifocal motor neuropathy (MMN), amyotrophic lateral sclerosis (ALS), and healthy volunteers

Visualization of nerves and muscles in the forearm - In patients with multifocal motor neuropathy (MMN), amyotrophic lateral sclerosis (ALS), and healthy volunteers - VISA study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40757

Enrollment

Registered

2014-06-16

Start date

2014-07-22

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

multifocal motor neuropathy and amyotrophic lateral sclerosis peripheral neuropathy and muscular atrophy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with MMN * Slowly progressive or stepwise progressive limb weakness * Asymmetrical limb weakness * Number of affected limb regions

Exclusion criteria

Exclusion criteria: Patients with MMN * The patients should have no objective sensory abnormalities except for vibration sense * The patients should have no bulbar signs or symptoms * The patients should have no upper motor neuron features * The patients should have no other neuropathies (eg, diabetic, lead, porphyric or vasculitic neuropathy; chronic inflammatory demyelinating polyneuropathy; Lyme neuroborreliosis; postradiation neuropathy; hereditary neuropathy with liability to pressure palsies; Charcot-Marie-Tooth neuropathies; meningeal carcinomatosis) * The patients should have no myopathy (eg, facioscapulohumeral muscular dystrophy, inclusion body myositis);Patients with ALS * Patients should not have other disease processes that might explain the signs of lower/upper motor neuron degeneration * The patients should have no other neuropathies (eg, diabetic, lead, porphyric or vasculitic neuropathy; chronic inflammatory demyelinating polyneuropathy; Lyme neuroborreliosis; postradiation neuropathy; hereditary neuropathy with liability to pressure palsies; Charcot-Marie-Tooth neuropathies; meningeal carcinomatosis) * The patients should have no myopathy (eg, facioscapulohumeral muscular dystrophy, inclusion body myositis);Healthy controls * Volunteers with contra-indications for MRI (like a pacemaker, claustrophobia). * Volunteers with known MMN, ALS or other neuropathy related disease

Design outcomes

Primary

Measure	Time frame
The main study parameters will be on the one hand qualitative in terms of anatomy based on the anatomical MRI images (T1 and T2 sequences and 3D DTI tractography) and ultrasound images, and on the other hand quantitative in terms of diffusion parameters including the fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity and ultrasound measurements including the cross sectional nerve and fascicle area, nerve length and echogenicity. These results will be compared to the EMG. With EMG it is possible to obtain information regarding the nerve and muscle conduction. Potential differences in conduction will be compared to ultrasound and MRI parameters.	—

Measure

Time frame

The main study parameters will be on the one hand qualitative in terms of anatomy based on the anatomical MRI images (T1 and T2 sequences and 3D DTI tractography) and ultrasound images, and on the other hand quantitative in terms of diffusion parameters including the fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity and ultrasound measurements including the cross sectional nerve and fascicle area, nerve length and echogenicity. These results will be compared to the EMG. With EMG it is possible to obtain information regarding the nerve and muscle conduction. Potential differences in conduction will be compared to ultrasound and MRI parameters.

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Countries

Netherlands

Outcome results