Multicenter implementation of MR imaging studies in children with retinoblastoma for assessment of the value of craniofacial MRI screening of irradiated hereditary retinoblastoma survivors for early detection of second primary craniofacial tumors and to enhance survival

Multicenter implementation of MR imaging studies in children with retinoblastoma for assessment of the value of craniofacial MRI screening of irradiated hereditary retinoblastoma survivors for early detection of second primary craniofacial tumors and to enhance survival - SPT screening in irradiated hereditary retinoblastoma survivors

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40748

Enrollment

Registered

2014-05-16

Start date

2014-10-02

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

maligne tweede primaire tumoren bij erfelijke retinoblastoomoverlevers new tumors in hereditary retinoblastoma second primary tumors in hereditary retinoblastoma

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Hereditary retinoblastoma patients of 8 through 18 years old that were irradiated for their eye tumors

Exclusion criteria

Exclusion criteria: claustrofobia foreign non-MR compatible objects in the body

Design outcomes

Primary

Measure	Time frame
To evaluate the ability of craniofacial MRI to detect SPTs early we will determine the sensitivity and specificity of MRI at detecting SPTs in irradiated hereditary retinoblastoma patients.	—

Secondary

Measure	Time frame
1. Five-year (overall and event-free) survival. 2. Total number of MR scans performed to detect one SPT.	—

Countries

Netherlands

Outcome results