Influence of BCG vaccine as a booster for TDaP-IPV vaccination

Influence of BCG vaccine as a booster for TDaP-IPV vaccination - Influence of BCG

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON40745

Enrollment

Registered

2014-11-13

Start date

2015-01-29

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pertussis Whooping cough

Interventions

BCG vaccination Vaccination with Boostrix Polio

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy adults

Exclusion criteria

Exclusion criteria: Systemic medication other oral contraceptives. Diseases resulting in immunodeficiency. Previous BCG vaccination. Pregnancy.

Design outcomes

Primary

Measure	Time frame
Comparison of pertussis-specific antibody and T-cell responses, as well as gene transcription between BCG, TDaP-IPV and BCG+TDaP-IPV vaccinated groups. Comparison of cytokine responses to unrelated antigens and/or pathogens before and after BCG, TDaP-IPV or BCG+TDaP-IPV vaccination.	—

Secondary

Measure	Time frame
Epigenetic markers associated with immune function.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)