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Thiazide diuretics versus calcium channel blockers for the treatment of calcineurin inhibitor-induced hypertension in patients with psoriasis or eczema: a single-center randomized cross-over trial.

Thiazide diuretics versus calcium channel blockers for the treatment of calcineurin inhibitor-induced hypertension in patients with psoriasis or eczema: a single-center randomized cross-over trial. - TT-study Dermatology

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON40718
Enrollment
22
Registered
2014-03-11
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension or high blood pressure

Interventions

Patients will be randomized to receive chlorthalidone (12.5 mg once daily, if needed titrated to 25 mg once daily) and amlodipine (5 mg once daily, if needed titrated to 10 mg once daily) in success

Sponsors

Erasmus MC, Universitair Medisch Centrum Rotterdam
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Treatment with cyclosporine * MDRD-GFR * 30 ml/min * Systolic blood pressure > 140 mmHg but

Exclusion criteria

Exclusion criteria: * MDRD-GFR 1.0 g/10 mmol creatinine * Systolic blood pressure

Design outcomes

Primary

MeasureTime frame
Change in average 24-hour systolic blood pressure after eight weeks of treatment.—

Secondary

MeasureTime frame
* Incidence of hyperkalemia (serum potassium > 5.0 mmol/l) * Incidence of non-anion gap metabolic acidosis (serum bicarbonate—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)