Phospholipid and energy metabolism in the healthy aging brain

Phospholipid and energy metabolism in the healthy aging brain - Brain metabolism in healthy aging

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40713

Enrollment

Registered

2014-06-11

Start date

2014-07-10

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gezonde veroudering aging healthy aging

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: aged 60 years or older

Exclusion criteria

Exclusion criteria: Significant neurological or psychiatric disease MRI contra-indications Use within two months prior to visit of: - omega-3 fatty acid containing supplements - oily fish (when consumed more than twice a week) Use within one month prior to visit of: - vitamins B, C and/ or E > 200% RDA

Design outcomes

Primary

Measure	Time frame
Outcome measures are relative metabolite levels of the phosphomonoesters phosphocholine and phosphoethanolamine, and of the phosphodiesters glycerophosphocholine and glycerophosphoethanolamine to total phosphorus signal, the ratio of phosphomonoesters to phosphodiesters, and relative metabolite levels of alpha, beta and gamma adenosinetriphosphate, phosphocreatine, inorganic phosphate and nicotinamide adenine dinucleotide to total phosphorus signal.	—

Measure

Time frame

Outcome measures are relative metabolite levels of the phosphomonoesters phosphocholine and phosphoethanolamine, and of the phosphodiesters glycerophosphocholine and glycerophosphoethanolamine to total phosphorus signal, the ratio of phosphomonoesters to phosphodiesters, and relative metabolite levels of alpha, beta and gamma adenosinetriphosphate, phosphocreatine, inorganic phosphate and nicotinamide adenine dinucleotide to total phosphorus signal.

—

Secondary

Measure	Time frame
Blood parameters: Fatty acid profile in erythrocyte membrane, fatty acid profile in plasma, Choline, Homocysteine, Vitamin E, Uridine, and optionally, plasma phospholipids.	—

Countries

Netherlands

Outcome results