The Development of Advanced Reading Skills: Normalization and Compensation Effects among Children with a Familial Risk of Dyslexia - an fMRI study

The Development of Advanced Reading Skills: Normalization and Compensation Effects among Children with a Familial Risk of Dyslexia - an fMRI study - Normalization and Compensation in Dyslexia - an fMRI study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40707

Enrollment

Registered

2014-04-25

Start date

2014-05-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyslexie specific reading disability wordblindness

Interventions

None listed

Eligibility

Age

12 Years to 17 Years

Inclusion criteria

Inclusion criteria: - Children who have participated in EEG study (METc 2012/076) - Parental informed consent for participation - Child*s informed consent for participation - Agreeing that any abnormal findings with medical consequences will be communicated to the parents and the child*s general practitioner

Exclusion criteria

Exclusion criteria: - Uncorrected abnormal vision - Hearing problems - Brain damage as a result of head trauma or a medical condition - Serious health or psychiatric problems as reported by the parents - MR-related exclusion criteria: o Presence of metal implants (including some non-removable braces) o Presence of electronic implants (e.g., heart pacemakers) and connectors of electronic devices (e.g., implanted electrodes) o (possible) pregnancy o claustrophobia

Design outcomes

Primary

Measure	Time frame
- Performance (speed and accuracy) on behavioural tests investigating among others: second language reading comprehension, text reading, word reading, vocabulary, spelling and phonemic awareness. - Patterns of blood-oxygen level dependent (BOLD) activation related to the different language tasks that participants will execute while being scanned, compared between groups (control group, at-risk group without dyslexia, at-risk group with dyslexia), taking performance on the tasks into account. - Patterns of brain structural connectivity (localized fractional anisotropy (FA)) as obtained from DTI.	—

Measure

Time frame

- Performance (speed and accuracy) on behavioural tests investigating among others: second language reading comprehension, text reading, word reading, vocabulary, spelling and phonemic awareness. - Patterns of blood-oxygen level dependent (BOLD) activation related to the different language tasks that participants will execute while being scanned, compared between groups (control group, at-risk group without dyslexia, at-risk group with dyslexia), taking performance on the tasks into account. - Patterns of brain structural connectivity (localized fractional anisotropy (FA)) as obtained from DTI.

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Countries

Netherlands

Outcome results