Gastric emptying Hormonal changes Transit time
Conditions
Interventions
None listed
Sponsors
Rijnstate Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: I. Patients who are approaching their two years follow-up after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) and Laparoscopic Sleeve Gastrectomy (LSG) are eligble for inclusion. The patients will be arranged in one of the following four groups according to the Reinhold*s criteria:;- Good responders (EWL > 50%) two years after RYGB - Bad responders (EWL 50%) two years after LSG - Bad responders (EWL
Exclusion criteria
Exclusion criteria: - Binge-eating or associated eating disorder - Active drug or alcohol addiction - Gluten allergy - Inability to stop medication that affects the motility of the upper gastrointestinal tract (anti-cholinergic drugs, prokinetics, theophylline, calcium blocking agents, opioids) - Endocrine disease influencing gastric emptying (diabetes mellitus, hyper- or hypothyroidism). T2DM is not an exclusion criteria for patients receiving the DJBL because T2DM is a requirement for receiving the DJBL. Additionally, changes in GE rate will be determined 1 month after implantation. No significant changes in GE rate will be expected in this time period caused by their T2DM
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastric emptying rate and incretin levels two years after LRYGB and LSG, and gastric emptying before and 1 month after DJBL implantation. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Weight loss/ excess weight loss two years after Roux-en-Y Gastric Bypass and Sleeve Gastrectomy - Quality of life two years after Roux-en-Y Gastric Bypass and Sleeve Gastrectomy - Quality of life before and one month after implantation of the duodenal-jejunal bypass liner | — |
Countries
Netherlands
Outcome results
None listed