Muscle metabolism Disuse atrophy
Conditions
Interventions
Twice daily neuromuscular electrical stimulation (NMES) or no intervention.
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Unilateral closed ankle fracture (Weber type A, B or C) - Aged from 18-65 years - BMI above 18.5 and below 30 kg/m2 - Undergoing surgical treatment
Exclusion criteria
Exclusion criteria: - Additional fractures beside ankle fracture (e.g. multi-trauma following a car accident) - Use of oral anticoagulants such as vitamin K-antagonists (e.g. acenocoumarol and fenprocoumon) and direct-acting or new oral anticoagulants (e.g. apixaban, dabigatran and rivaroxaban) - Any family history of thrombosis - All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis) - Myocardial infarction within the last 3 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Calf muscle (gastrocnemius) cross sectional area (CSA). | — |
Secondary
| Measure | Time frame |
|---|---|
| Type I and II muscle fiber CSA and SC content, intramuscular triglyceride content and mRNA and protein expression of anabolic signaling proteins. | — |
Countries
Netherlands
Outcome results
None listed