Regulation of lipid metabolism by fructose versus glucose in obese humans with and without hepatic steatosis and its relation to insulin sensitivity

Regulation of lipid metabolism by fructose versus glucose in obese humans with and without hepatic steatosis and its relation to insulin sensitivity - Carbohydrate regulation of lipids

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40700

Enrollment

Registered

2014-09-29

Start date

2015-08-17

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

metabolic syndrome non-alcoholic fatty liver disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -eligible and scheduled for bariatric surgery (gastric bypass) -18-65 years of age -ability to provide informed consent -stable weight 3 months prior to inclusion -willingness to stop lipid lowering medication 4 weeks prior to start

Exclusion criteria

Exclusion criteria: -primary lipid disorder -childhood onset obesity (i.e. 150/95 mmHg) -renal insufficiency (plasma creatinin >150 umol/l) -excessive alcohol intake (>14 units/week) -pregnancy, breastfeeding -contraindication to MR scanning (e.g. pacemaker, metallic foreign body, claustrophobia)

Design outcomes

Primary

Measure	Time frame
Differences in regulation of lipogenic pathways in insulin-sensitive tissues by fructose versus glucose intake in obese humans with or without hepatic steatosis.	—

Secondary

Measure	Time frame
-regulation of de novo lipogenesis (lipid flux) in response to oral fructose or glucose -the role of important lipogenic enzymes (such as ChREBP-/ and FGF21) in de novo lipogenesis, fat distribution and ectopic fat accumulation -the role of these pathways in peripheral and hepatic insulin resistance and endogenous glucose production-differences in lipid species composition in relation to gene expression profiles and lipid and glucose fluxes -differences in de novo lipogenesis, fat distribution and ectopic fat accumulation in relation to systemic and hepatic insulin resistance	—

Measure

Time frame

-regulation of de novo lipogenesis (lipid flux) in response to oral fructose or glucose -the role of important lipogenic enzymes (such as ChREBP-*/* and FGF21) in de novo lipogenesis, fat distribution and ectopic fat accumulation -the role of these pathways in peripheral and hepatic insulin resistance and endogenous glucose production-differences in lipid species composition in relation to gene expression profiles and lipid and glucose fluxes -differences in de novo lipogenesis, fat distribution and ectopic fat accumulation in relation to systemic and hepatic insulin resistance

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Countries

Netherlands

Outcome results