THE EFFECT OF REPEATED REMOTE ISCHEMIC PRECONDITIONING ON ENDOTHELIAL FUNCTION AND INNATE IMMUNE RESPONSES IN PATIENTS WITH END-STAGE RENAL DISEASE

THE EFFECT OF REPEATED REMOTE ISCHEMIC PRECONDITIONING ON ENDOTHELIAL FUNCTION AND INNATE IMMUNE RESPONSES IN PATIENTS WITH END-STAGE RENAL DISEASE - repeated IPC

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON40693

Enrollment

Registered

2014-12-15

Start date

2016-01-01

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

kidney disease patients with dialysis

Interventions

7 day, daily, unilateral IPC (4X5-minutes of occlusion of the upper arm using a blood pressure cuff)

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Patients with chronic kidney disease (CKD stage 4 or 5)

Exclusion criteria

Exclusion criteria: • The presence of a patent arterio-venous fistula (for dialysis) • Simultaneous participation in another interventional study • Impossibility to perform RIPC, due to pathology of both arms (for example, sclerodermia, dystrophy, recent trauma, chronic wounds)

Design outcomes

Primary

Measure	Time frame
The change in endothelial function after a 7-day intervention (measured as the brachial artery flow-mediated dilation for the primary objective and contra-lateral brachialartery flow-mediated dilation for the secondary objective).	—

Secondary

Measure	Time frame
brachial artery endothelial function in the dominant arm after ischemia-reperfusion injury	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)