Does upregulation of microRNA 'x' influence monocyte function of smoking individuals with subclinical atherosclerosis?

Does upregulation of microRNA 'x' influence monocyte function of smoking individuals with subclinical atherosclerosis? - microRNA 'x' and monocytes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40682

Enrollment

Registered

2014-03-26

Start date

2014-05-26

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atherosclerosis cardiovascular disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - smoking - known calcium score assessed with a coronary CT scan - known microRNA 'x' levels

Exclusion criteria

Exclusion criteria: Patients in which statin therapy is a necessity according to standard European guidelines.

Design outcomes

Primary

Measure	Time frame
monocyte function by FACS analysis and cytokine measurement after LPS stimulation. Moreover, we will perform ChIP analysis for epigenetics and measure gene expression levels in the monocytes.	—

Secondary

Measure	Time frame
none	—

Countries

Netherlands

Outcome results