Congenital long QT syndrome LQTS
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
12 Years to 99 Years
Inclusion criteria
Inclusion criteria: All girls and boys born between January 1st 1985 and December 31st 2001, who are diagnosed based on their genotype with LQT1 or LQT2 and seen in the Academic Medical Centre in Amsterdam between January 1st 2003 and December 31st 2013, will be included in the study population.
Exclusion criteria
Exclusion criteria: - Premenarcheal - Pregnancy - Use of hormonal contraceptive therapy other than combined estrogen-progestin oral contraceptives (i.e. intrauterine contraception, contraceptive vaginal ring, etonogestrel contraceptive implant, injectable contraceptives or progestin pills) - Double mutation carriers or compound heterozygote - Body mass index (BMI) for age greater than the 95th percentile - History of polycystic ovary syndrome (PCOS)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The QTc interval will be measured pre- and post-menarche and during 3 phases of the menstrual cycle. In boys QTc interval will be measured at approximately the same time intervals as the girls during their menstrual cycle. | — |
Countries
Netherlands
Outcome results
None listed