life-threatening heart rythm disorder ventricular fibrillation
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All documented patients who had an OHCA, who were successfully resuscitated and had ventricular fibrillation as initial rhythm and were finally diagnosed as idiopathic VF.
Exclusion criteria
Exclusion criteria: N/A
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alternative diagnoses discovered during follow-up in patients with IVF. | — |
Secondary
| Measure | Time frame |
|---|---|
| • Description of the population of our cohort (Prognosis, recurrence of arrhythmias, therapy, (in)appropriate shocks, presence of cardiac anomalies not sufficient for an alternative diagnosis) • The detection of prognostic factors for IVF (family history, use of medication, gender, ECG features etc). • Discovering new susceptibility genes for idiopathic VF In patients who have no structural or electrical heart disease nor a known gene mutation responsible for ventricular fibrillation, we will pursue a *hypothesis- driven* approach and search for mutations in genes that are predicted to be of importance in IVF, based on existing gene networks and existing literature. When no susceptibility genes are discovered, sequencing will be extended to whole exome sequencing. • Quality of life measurements of IVF patients, compared to the healthy population. | — |
Countries
Netherlands
Outcome results
None listed