gastro-intestinal permeabilty gut barrier function intestinal integrity
Conditions
Interventions
Ingestion of multi sugar and glutamine- alanine solutions to evaluate gut
function. 5 different exercise conditions as described in study design
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Male • Generally healthy • Recreational athlete with at least two years of cycling experience of at least twice a week • 18-35 years old • Meeting criteria of valid max-test • Body mass index (BMI) 20-25 kg/m2 • Veins suitable for blood sampling at inspection
Exclusion criteria
Exclusion criteria: • Known symptoms of immune diseases such as diabetes, celiac disease, gastric disease or cystic fibrosis • Known symptoms of intestinal diseases such as Crohn*s disease, ulcerosis, irritable bowel syndrome or cystic fibrosis • Smoking • Use of hard drugs • Use of specific medicines: o Chronic use of NSAIDs: aspirin, ibuprofen, etc. o Drugs for gastric and/or intestinal function • Participation in other scientific studies • Blood donation during the last six weeks prior to the start of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are the relative increase in intestinal permeability (lactulose/rhamnose ratio) and plasma levels of glutamine and glutamine-derived amino acids. | — |
Secondary
| Measure | Time frame |
|---|---|
| As secondary endpoints several markers of gastro-intestinal integrity and inflammation are studied in blood, urine and saliva. | — |
Countries
Netherlands
Outcome results
None listed