*T1-mapping for functional MR imaging of the liver in Primary Sclerosing Cholangitis

*T1-mapping for functional MR imaging of the liver in Primary Sclerosing Cholangitis - *T1 in PSC

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40638

Enrollment

Registered

2014-11-27

Start date

2015-02-13

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary Sclerosing Cholangitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - 18 years or older - Proven prior diagnosis of Primary Sclerosing Cholangitis (based on laboratory and clinical findings and biopsy and/or ERCP and/or MRCP results) - Clinically suspected dominant stricture causing acute pruritus and jaundice with indication for urgent MRCP and ERCP - Written, informed consent

Exclusion criteria

Exclusion criteria: - Contraindications for MRI - Known haemochromatosis - Chronic renal insufficiency or eGFR

Design outcomes

Primary

Measure	Time frame
- Quantitative MRI: *T1 - MRCP/ERCP: location and degree of bile duct obstruction	—

Secondary

Measure	Time frame
- Laboratory values: e.g. AP, gGT, billirubin (as measure of cholestasis) - Liver fat percentages (MR fat mapping) - Bile composition (using in vitro, high-field MR Spectroscopy)	—

Countries

Netherlands

Outcome results