hypothyroidism urinary concentrating ability
Conditions
Interventions
14 hour fasting.
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: patient with differentiated thyroid carcinoma Have the capacity to understand and willingness to sign an informed consent form. Aged 18-65 years Estimated kidney function, eGFR >60 mL/min per 1.73 m2
Exclusion criteria
Exclusion criteria: Alcohol abuse Other malignancy Clinically relevant active systemic disease (such as autoimmune or infectious diseases) Pregnancy Use of drugs interfering with thyroid hormone metabolism (e.g. antiepileptic drugs, amiodarone, and lithium) or influencing renal concentration capacity (i.e. diuretics) Other primary thyroid disease History of diabetes insipidus, diabetes mellitus, adrenal deficiency, chronic kidney disease Urinary tract infection or menstruation at the time of inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be a significant difference in maximal urine osmolality after water deprivation in euthyroid and hypothyroid state. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome is a difference in heart rate, urinary water and salt transporter excretion in urinary microvesicles (both protein and RNA abundance) and vasopressin/ copeptin levels after water deprivation. | — |
Countries
Netherlands
Outcome results
None listed