traumatic memory and pathological fear
Conditions
Interventions
In study arm 1, half of the subjects will undergo a stress induction protocol
involving highly aversive cinematographic material and (threat of) mild
electrical stimulation to the fingers.
In the
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: •Healthy volunteers between 18 and 45 years of age (balanced for gender) •Predominant right-handedness.
Exclusion criteria
Exclusion criteria: • Abnormal hearing or (uncorrected) vision. • Average use of more than 3 alcoholic beverages daily. • Average use of psychotropic medication or recreational drugs weekly or more. • Habitual smoking, i.e. more than a package of cigarettes per week and a self-reported inability or unease to cease smoking for 24 hours prior to testing. • Use of psychotropic medication, or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement. • Regular use of corticosteroids. • Metal objects in or around the body (braces, pacemaker, metal fragments, hearing devices). • History of psychiatric treatment or current psychiatric treatment. • History of neurological treatment or current neurological treatment. • History of endocrine treatment or current endocrine treatment. • History of autonomic failure (e.g., vasovagal reflex syncope). • Current parodontitis (only in study arm 1). • Claustrophobia. • Intense daily physical exercise. • Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel). • BDI score higher than 13.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Magnetic Resonance Imaging (fMRI) Behavioural measures (e.g. memory accuracy and response bias) | — |
Secondary
| Measure | Time frame |
|---|---|
| Salivary levels of cortisol and alpha-amylase Psychophysiological recordings (pupil dilation, respiration, heart rate, skin conductance, blood pressure) | — |
Countries
Netherlands
Outcome results
None listed