atopic dermatitis
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: 100 children with atopic dermatitis, male or female, aged between 0 and 12 years, will be participating in this study.;50 children without any skin disorder or atopy (such as food allergy, allergic rhinoconjunctivitis and allergic asthma), as well as no atopy in first degree relatives, male or female, aged between 0 and 12 years, will be participating as controls
Exclusion criteria
Exclusion criteria: For Cases: No clinically skin lesion to obtain tape strips from. Use of corticosteroids or other anti-inflammatory topical treatment on the skin lesion(s) selected for tape stripping 1 week prior to the procedure. Use of emollients, soap, and cosmetics on the skin lesion(s) selected for tape stripping 48 hours prior to and during the hospital visit day. Use of oral antihistamin 1 week prior to the hospital visit day. - Onset of atopic dermatitis after the age of 2 - History of remission of atopic dermatitis without treatment (except emollients) for longer than 1 year ;For controls: history of atopy or first degree relative with atopy Use of emollients, soap, and cosmetics on the skin lesion(s) selected for tape stripping 48 hours prior to and during the hospital visit day.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical and biochemical parameters in relation to the presence of AD and FLG mutations. | — |
Secondary
| Measure | Time frame |
|---|---|
| Establishment of different phenotypes of AD based on the relationschip FLG genotype and biochemical parameters | — |
Countries
Netherlands
Outcome results
None listed