Chronic Obstructive Pulmonary Disease COPD lung emfysema and chronic bronchitis
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male or Female, 40 years or older Doctor*s diagnosis of COPD. Experiencing an exacerbation of COPD requiring hospitalization at the moment of inclusion. An exacerbation is defined as a worsening of respiratory symptoms from the stable state and beyond normal day-to-day variations, which requires additional treatment. Patients must be able to understand and complete protocol requirements, Instructions and questionnaires in Dutch Written Informed consent
Exclusion criteria
Exclusion criteria: If any of these criteria are absent at admission, but occur during the course of the study, patients will be followed up within the protocol as much as possible. Pneumonia confirmed with X ray COPD exacerbation requiring (non) invasive ventilation or admittance to an intensive care unit Patient who received any investigational new drug within the last 4 weeks prior to admission or twice the duration of the biological half-life of any investigational new drug (whichever is longer). Unstable angina pectoris or other clinically important cardiac co-morbidity requiring admission on a cardiology ward
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Temporal relation between changes in hyperinflation (as measured by inspiratory capacity) during resolution of the exacerbation, and changes in HR-QoL and dyspnoea. | — |
Secondary
| Measure | Time frame |
|---|---|
| Other HR-QoL and dyspnea patient report outcomes (PRO)'s Lung function parameters: dynamic hyperinflation, TLC, diffusion, FEV1, FVC, IOS, single breath nitrogen washout. Enose for measurement of exhaled organic compounds Inflammation parameters measured by blood sample and nasopharyngeal swab Infection as assessed by routine lab and cultures Length of stay in the hospital | — |
Countries
Netherlands
Outcome results
None listed