Subjective cognitive impairment and mild cognitive impairment: a sign of incipient Alzheimers disease? A longitudinal study of functional and structural brain changes in healthy older adults with and without cognitive complaints.

Subjective cognitive impairment and mild cognitive impairment: a sign of incipient Alzheimer*s disease? * A longitudinal study of functional and structural brain changes in healthy older adults with and without cognitive complaints. - Subjective cognitive impairment: a sign of incipient AD?

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40552

Enrollment

Registered

2014-03-05

Start date

2014-09-23

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

memory complaints Subjective cognitive impairment

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy adults aged 40-90 with or without memory complaints. Adults with SCI must have undergone a formal medical assessment that concluded that no objective cognitive impairment was apparent. Adults with MCI must have undergone a formal medical assessment that concluded that impairment in memory and intraindividual change was apparent, but no evidence of a significant impairment in social or occupational functioning.

Exclusion criteria

Exclusion criteria: Left-handedness; any significant diagnosed medical, neurological or psychiatric illness; a history of brain damage; or the use of psychoactive medication will exclude volunteers from participating. Participants will also disqualify if they have any MRI contraindications such as: implanted electrical device (e.g., cardiac pacemaker) or metallic clip (e.g., aneurysm clip). We will also warn participants that some individuals experience claustrophobia in the scanner. We will seek equal representations of men and women.

Design outcomes

Primary

Measure	Time frame
1) MRI (resting state fMRI, task related fMRI, DWI and structural MRI), 2) cognitive parameters, 3) APOE * genotype.	—

Countries

Netherlands

Outcome results