depressieve stemmingsstoornissen en afwijkingen dystonia (there are no synonyms)
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with clinically confirmed diagnosis of idiopathic cervical dystonia (CD) or Carrier of mutation in DYT11 gene for myoclonus-dystonia (MD) or Carrier of mutation in GTP-cyclohydrolase 1 gene for dopa-responsive dystonia (DRD) Only adults ( >= 18 years old) will be eligible for PET-scans
Exclusion criteria
Exclusion criteria: General exclusion criteria: other neurological conditions past of present, treatment with deep brain stimulation ;Additional exclusion criteria from the PET-scanning: - SSRI use in the past 6 months to or during the study - use of medication with a known effect on serotonin receptors or transporters - pregnancy or nursing - exhibition to a radiation dose for other reasons, exceeding the maximum annual dose
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the proportion of dystonia patients having psychiatric co-morbidity, compared to the proportion having psychiatric symptoms in a healthy control population (part A), and the percentage difference in serotonin metabolism (serotonin transporter (SERT) on a [11C]DASB PET scan between subjects with dystonia and healthy controls, and between subjects with and without psychiatric disorders (part B). Serotonin metabolism will be assessed as [11C]-DASB binding potential (BP) as outcome measure for SERT availability in different brain regions of interest (ROIs): brainstem, striatum and frontal cortex. Additionally, a whole brain voxelwise comparison will be performed using Statistical Parametric Mapping (SPM). | — |
Secondary
| Measure | Time frame |
|---|---|
| Motor assessment: Severity of dystonia, severity of myoclonic symptoms, clinical severity Psychiatric assessment Adults: the presence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-VI) diagnosis, Life-time prevalence of any psychiatric diagnosis, severity of anxiety symptoms, severity of panic symptoms, severity of social anxiety symptoms and avoidance, severity of OCD symptoms, severity of depressive symptoms Children: the presence of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-VI) diagnosis Concentrations of serotonin in platelets Genetics: the presence of polymorphisms of 5-HTTLPR (serotonin-transporter-linked polymorphic region), DNA methylation rate of the serotonin transporter gene | — |
Countries
Netherlands
Outcome results
None listed