Chronic Obstructive Pulmonary Disease
Conditions
Interventions
None listed
Sponsors
CIRO+ B.V.
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients: * Diagnosis: COPD according to the Global Initiative For Chronic Obstructive Lung Disease (GOLD) definition;Matched control group: * Smoking status comparable with smoking status from included patient (current smoker; non smoker; former smoker)
Exclusion criteria
Exclusion criteria: Patients: * Patient is not clinically stable during 4 weeks preceding enrolment * Previous diagnosis of dementia * Patient does not speak Dutch well enough to participate ;Brain MRI patient group: * The patient has a pacemaker or a cochlear implant * The patient has a neurostimulator or other electronic implants * The patient ever had surgery with metal implants (e.g. a magnetic implant within the jaw) * The patient ever had a metal splinter in the eye * The patient suffers from claustrophobia ;Matched control group: * Diagnoses of COPD or Asthma * Previous diagnosis of dementia * Participant does not speak Dutch well enough to participate * Age of the matched control differ more than 10 years from the age of the patient for who he/she was matched * Level of education of the matched control differs more than 1 level from the level of education for who he/she was matched (according to the scoring system of the CBS).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 4 compound scores for the cognitive domains: motor speed, memory, cognitive flexibility and planning. Furthermore: general cognitive functioning (cognitive index; MMSE)), IQ (GIT) and subjective cognitive functioning (CFQ). | — |
Secondary
| Measure | Time frame |
|---|---|
| * Demographics: age, level of education and social status. * Clinical characteristics: - General psychological functioning: Symptom Checklist-90, Hospital Anxiety and Depression scale, Beck Depression Inventory, Utrecht coping list, Dutch personality questionnaire en St George's Respiratory Questionnaire. - Other clinical characteristics: blood gasses, comorbidities (Charlson comorbidity index), pulmonary function, diffusion capacity, saturation measure, Obstructief Slaap Apneu Syndroom, medication, oxygen therapy, smoking behaviour, Body Mass Index, knowlegde about the lung disease, educational needs and exercise capacity (6-minute walking distance test). * Problematic activities of daily life (*Canadian Occupational Performance Measure*). * Patient information needs (Lung Information Needs Questionnaire). * Brain abnormalities, including brain atrophy, white matter lesions, hippocampal volume, vascular abnormalities, structural connectivity and functional connectivity | — |
Countries
Netherlands
Outcome results
None listed