Autism
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: ASD group: (1) Males and females aged 6-30 years with an established diagnosis of Autism Spectrum Disorder according to DSM-IV; idiopathic and syndromic forms of ASD (e.g., Fragile X, Rett Syndrome) are allowed (2) Males and females with IQ 50+ (3) All comorbidities (e.g., ADHD, anxiety) allowed except for psychosis and bipolar disorder (4) Informed written consent; (a) Where participants are their own legal guardian (i.e. aged 18 years and older without learning difficulties and demonstrated capacity to consent), written consent from the volunteer; (b) Where participants are minors and/ or do not have capacity to consent, written informed consent from the parent or legal guardian; verbal assent from the volunteer prior to each assessment (5) Availability of parent or caregiver who accompanies the volunteer to all institute visits and provides information about the volunteer*s behavior and symptoms. For adults with ASD who are their own legal guardian, availability of a parent who provides information about behavior/ symptoms during the institute visit, a separate home-visit or over the telephone. (6) Participant on stable medication (min 8 weeks) at entrance point and over the course of study allowed Typically Developing (TD) control group: Males and females aged 6-30 years Learning Difficulties (LD) control group: Males and females aged 13-30 years Syndromic forms of LD (Down*s Syndrome) and unspecified general learning disabilities allowed
Exclusion criteria
Exclusion criteria: (1) Significant hearing or visual impairments not correctable by glasses or hearing aids (2) Alcohol and / or substance abuse or dependence in the past year (3) Any MRI counter-indications (e.g., metal implants, braces) ASD and LD group: presence of psychosis or bipolar disorder TD group: presence of any DSM-V axis I and II psychiatric disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Phenotyping of ASD will involve questionnaires and semi-structured interviews probing the presence and severity of ASD. The MRI session includes structural MRI, resting state, DTI and fMRI. Outside the scanner several computer based tasks will be conducted to assess cognitive abilities. Eye-tracking and EEG tasks will also be performed outside the scanner. | — |
Countries
Netherlands
Outcome results
None listed