Obesitas Obesity overweight
Conditions
Interventions
Each participant receives &Delta
9-tetrahydrocannabinol (THC), cannabidiol (CBD) or
placebo in three separate sessions that will be at least two weeks apart.
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male Healthy Incidental user of Cannabis
Exclusion criteria
Exclusion criteria: Previously experienced an adverse reaction to cannabinoids (e.g. anxiety, paranoia, naussea, vomiting) Having a family history of schizophrenia or other psychotic ilness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the sucrose intensity scaling (psychophysics) and liking (psychohedonics) of the milkshakes with the different sucrose concentrations. | — |
Secondary
| Measure | Time frame |
|---|---|
| The first secondary objective it to assess if cannabinoids influence the preferred sucrose concentration and the total amount of milkshake consumed in the preference task. The second secondary objective is to see if the blood levels of endocannabinoids, leptin, ghrelin and insulin change during the course of the session and if there are differences between sessions. The third secondary objective is to follow plasma levels of THC or CBD and their active metabolites. The fourth secondary study objective is changes in liking of food products and in food choice in the food preference task. This also includes reaction time for the food choice questions. The fifth and final secondary study objective is the genetic determination of the enzymes responsible for the metabolism of THC and CBD. | — |
Countries
Netherlands
Outcome results
None listed