phantom sound perception Tinnitus
Conditions
Interventions
None listed
Sponsors
Clinical Trail Center Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: The main inclusion criteria of the tinnitus group are unilateral (i.e. tinnitus is experienced at one side of the head/at one ear), chronic (i.e. longer present than 6 months) and subjective (not caused by an acoustic source inside the head) tinnitus. Age between 18 and 75 years and a written informed consent prior to study initiation.
Exclusion criteria
Exclusion criteria: Exclusion criteria are: Fletcher Index > 50 dB HL for both ears (i.e. mean of hearing loss in decibels for 1 kHz, 2 kHz en 4 kHz), difference in average hearing threshold of more than 10 dB between left and right ear (large differences will influence the intra-individual analysis), hyperacusis (i.e. oversensitivity of sound), phonophobia (i.e. a persistent, abnormal and unwarranted fear of sound), misophonia (i.e. dislike of certain sounds), neurological-, neurosurgical- and psychiatric history, use of dopaminergic drugs (since this medication greatly influence the fMRI scans), morbid obesitas (BMI > 35) since it cannot be guaranteed that these subjects will fit in the scanner, current treatment of tinnitus and implanted devices or other metal objects that are not suitable for MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint will be the tonotopic map in auditory brainstem structures including the cochlear nucleus complex up to the inferior colliculus. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. fMRI activity in auditory brainstem structures 2. Structural (volumetric) measurements in auditory brainstem structures | — |
Countries
Netherlands
Outcome results
None listed