bowel ischemia mesenteric ischemia
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - > 18 yrs of age - capable of giving informed consent - patients suspected of chronic gastrointestinal ischemia referred to the Erasmus MC for analysis of complains;Healthy volunteers: - patent gastrointestinal arteries - unremarkable medical history - non-smoking
Exclusion criteria
Exclusion criteria: -
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - To determine the difference in baseline mucosal oxygen saturation measurements and after luminal feeding between patients diagnosed with CGI and healthy subjects. - To determine the difference in baseline mucosal oxygen saturation measurements prior to and after treatment inpatients diagnosed with CGI with persistent relief of symptoms after treatment. - To determine the microcirculatory perfusion before and 60 minutes after luminal feeding in patients with and without CGI, using the following measurement parameters: Total vessel density (TVD [mm/mm2] or [cpll/mm2]) Perfused vessel density (PVD [mm/mm2] or [cpll/mm2]) Vessel diameters (VD [µm]) RBC velocity (RBCv [µm /sec]) Proportion of perfused vessels (PPV [%]) Microvascular flow index (MFI [AU]) Flow heterogeneity (MFIhet [AU]) | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints: - To determine normal mucosal oxygen saturation measurements of the antrum, duodenal bulb and descending duodenum in healthy subjects using visible light spectroscopy. - To determine the effect of luminal feeding stimulation on mucosal oxygen saturation measurements of the antrum, duodenal bulb and descending duodenum in healthy subjects using visible light spectroscopy. - Presence of abdominal pain before and after luminal feeding stimulation, using the Numeric Pain Intensity Scale to assess the pain severity. - Time course response of luminal feeding stimulation on abdominal pain before and after 15 and 60 minutes of administering the compound liquid meal using the Numeric Pain Intensity Scale to assess the severity of pain. If pain is present, patients will be asked whether the pain is recognizable with the pain they experience after eating from before. - Presence of abdominal pain before and after luminal feeding stimulation using the Numeric Pain Intensity Scale-score to assess the pain severity in patients treated for CGI. - Time course response of luminal feeding stimulation on sublingual microcirculation before and 60 minutes of administering the compound liquid meal using the Cytocam hand-held microscope. | — |
Countries
Netherlands
Outcome results
None listed