Imaging vascularisation and morphometry in burns and scars by Optical Coherence Tomography

Imaging vascularisation and morphometry in burns and scars by Optical Coherence Tomography - Optical Coherence Tomography in burns and scars

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40457

Enrollment

Registered

2015-02-04

Start date

2015-06-15

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

1. Vascularisation en morphometry of burns and scars 2. Imaging of blood flow and tissue structure

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age > 18 years Competent or temporary incompetent (because of sedation and/or intubation) Acute burn wound and a planned operation of the burn wound or: Burn scar and an already planned excision (operation) of the scar

Exclusion criteria

Exclusion criteria: Language barrier Pre-existing vascular problems both acquired (venous or arterial diseases) or congenital (such as vascular malformations) (Possible) pregnancy

Design outcomes

Primary

Measure	Time frame
The main study parameter is the utility of OCT to perform objective assessment of the vascularisation and surrounding tissue in burns and scars. Based on previous studies we expect to see a loss of layered structure in (deep) burn wounds and reduced to absent vascularisation. Moreover, a smaller birefringence and collagen denaturation can be found in thermally injured skin. To quantify the vascularisation in scars, we endeavour to identify the diameter of blood vessels and obtain vessel density .	—

Measure

Time frame

The main study parameter is the utility of OCT to perform objective assessment of the vascularisation and surrounding tissue in burns and scars. Based on previous studies we expect to see a loss of layered structure in (deep) burn wounds and reduced to absent vascularisation. Moreover, a smaller birefringence and collagen denaturation can be found in thermally injured skin. To quantify the vascularisation in scars, we endeavour to identify the diameter of blood vessels and obtain vessel density .

—

Secondary

Measure	Time frame
- Scar: colour, elasticity, subjective scar outcome assessed by the POSAS. - Burn wound: depth assessment by the clinical impression of an experienced burn clinician. The secondary study parameters are not used for determination of the utility of OCT but may be used to perform additional analyses. E.g.: assessing agreement between colour measurement and vessel density assessed by OCT.	—

Countries

Netherlands

Outcome results