Screening for coronary artery disease using primary evaluation with coronary CTA in aviation medicine

Screening for coronary artery disease using primary evaluation with coronary CTA in aviation medicine - SUSPECT

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40436

Enrollment

250

Registered

2014-09-30

Start date

2014-11-17

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Military aircrew of the Royal Netherlands Airforce - >= 40 years old. - Required to undergo cardiac screening at the Centre for Man and Aviation (Centrum voor Mens en Luchtvaart (CML))

Exclusion criteria

Exclusion criteria: - Typical angina - Prior myocardial infarction - Prior revascularization therapy (i.e. percutaneous coronary intervention (PCI) and/or coronary artery bypass grafting (CABG)) - Left ventricular ejection fraction

Design outcomes

Primary

Measure	Time frame
a. Clinically significant CAD, defined as a stenosis >= 50% b. Clinically non-significant CAD, defined as a stenosis 30%-49%	—

Secondary

Measure	Time frame
1. To determine the diagnostic accuracy of the exercise stress test for: a. Clinically significant CAD, defined as a stenosis >= 50% b. Clinically non-significant CAD, defined as a stenosis 30%-49% 2. To compare the incidence of coronary angiograms and coronary revascularization procedures (i.e. PCI or CABG procedures) in the population screened with CTA compared to a historical population using CTA as a secondary screening tool 3. To establish the additive value of CACS in addition to clinical risk scores (European Society of heart Score or Framingham) as a predictor of CAD on CCTA.	—

Measure

Time frame

1. To determine the diagnostic accuracy of the exercise stress test for: a. Clinically significant CAD, defined as a stenosis >= 50% b. Clinically non-significant CAD, defined as a stenosis 30%-49% 2. To compare the incidence of coronary angiograms and coronary revascularization procedures (i.e. PCI or CABG procedures) in the population screened with CTA compared to a historical population using CTA as a secondary screening tool 3. To establish the additive value of CACS in addition to clinical risk scores (European Society of heart Score or Framingham) as a predictor of CAD on CCTA.

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Countries

Netherlands

Outcome results