Incidence of type 2 diabetes mellitus and cardiovascular disease in familial combined hyperlipidemia

Incidence of type 2 diabetes mellitus and cardiovascular disease in familial combined hyperlipidemia - Incidence of T2DM and CVD in FCHL

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40391

Enrollment

595

Registered

2014-05-12

Start date

2014-06-19

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

familial combined hyperlipidemia genetically elevated cholesterol and triglycerides levels

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All subjects, i.e. FCHL patients, their normolipidemic relatives and spouses, who have been included in our initial cohort (initiated in 1998) wil be invited for this study

Exclusion criteria

Exclusion criteria: As this study is a follow-up study, all subjects who have been included in the original cohort will be invited, except for: 1) subjects who have previously rejected any further participation 2) subjects with impaired cognitive function to give informed consent.

Design outcomes

Primary

Measure	Time frame
1) 10-years incidence of T2DM 2) 10-years incidence of CVD	—

Secondary

Measure	Time frame
1) Baseline predictors of incident T2DM; baseline predictors of interest are age, sex, body mass index, waist circumference, plasma glucose and insulin levels. Additional factors of interest are genetic factors. 2) Baseline predictors of incident CVD; baseline predictors of interest are age, sex, body mass index (BMI), waist circumference, systolic blood pressure, diastolic blood pressure, smoking status, plasma glucose, HDL-cholesterol, LDL-cholesterol, apolipoprotein B and total cholesterol levels, which have been determined at baseline in all subjects. 3) Compliance to current primary and secondary CVD prevention strategies; clinical parameters of interest are systolic and diastolic blood pressure, plasma HbA1c and LDL-cholesterol levels at follow-up. 4) The prevalence of CESD in dyslipidemic FCHL pedigrees	—

Measure

Time frame

1) Baseline predictors of incident T2DM; baseline predictors of interest are age, sex, body mass index, waist circumference, plasma glucose and insulin levels. Additional factors of interest are genetic factors. 2) Baseline predictors of incident CVD; baseline predictors of interest are age, sex, body mass index (BMI), waist circumference, systolic blood pressure, diastolic blood pressure, smoking status, plasma glucose, HDL-cholesterol, LDL-cholesterol, apolipoprotein B and total cholesterol levels, which have been determined at baseline in all subjects. 3) Compliance to current primary and secondary CVD prevention strategies; clinical parameters of interest are systolic and diastolic blood pressure, plasma HbA1c and LDL-cholesterol levels at follow-up. 4) The prevalence of CESD in dyslipidemic FCHL pedigrees

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Countries

Netherlands

Outcome results