sympathische zenuwstelsel en intrarenale zenuwen uptake and distribution of 123I-MIBG in the kidney (how much of the radioactive tracer 123I-MIBG is taken up by the kidney nerves)
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - age 18 to 85 years - able to give informed consent - scheduled for radical nephrectomy, nephron-sparing partial nephrectomy or nephroureterectomy (only scheduled on Tuesdays to Fridays)
Exclusion criteria
Exclusion criteria: - not willing to be informed about unexpected findings during the study - pregnancy - donor nephrectomy - nephrectomy scheduled on Mondays
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| to compare in vivo total kidney 123I-MIBG uptake (by counts per pixel) by 123I-MIBG scintigraphy to direct ex vivo 123I-MIBG uptake of the flushed kidney as directly assessed with phosphor imaging. | — |
Secondary
| Measure | Time frame |
|---|---|
| - to measure distribution of 123I-MIBG within the kidney - to compare the quantified 123I-MIBG and distribution of 123I-MIBG as assessed with phosphorus imaging to the histological distribution of sympathetic nerve endings by immunohistochemical neuron staining. - to compare 123I-MIBG uptake from in vivo renal 123I-MIBG scintigraphies, with 123I-MIBG uptake from ex vivo renal 123I-MIBG scintigraphies - to correlate the ex vivo renal 123I-MIBG scintigraphies with the direct ex vivo renal 123I-MIBG uptake as quantified by the phosphorus image plate. | — |
Countries
Netherlands
Outcome results
None listed