morbide obesitas corpulence morbid obesity
Conditions
Interventions
During fMRI measurements participants will be exposed to combinations of
pictures and odours, but also to odours alone. Pictures and odours that are
used are cues for food products (e.g. french frie
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Scheduled for Roux-en-Y gastric bypass surgery Age: 18-55 years (for food cue response-part: normosmic)
Exclusion criteria
Exclusion criteria: Being a vegetarian Allergic to food products used as stimuli in the study (for food cue response-part: not being MRI compatible, i.e. having pieces of metal in the body)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in food preferences before and after gastric bypass surgery. Difference in brain reward response to the smell and sight of food 2 weeks before and 8-10 weeks after gastric bypass surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective is to assess fasting plasma levels of endocannabinoids (eCB), ghrelin, leptin, adiponectin, GLP1 and insulin. Differences in brain reward response (fMRI) after exposure to sight+smell and after exposure to smell alone. | — |
Countries
Netherlands
Outcome results
None listed