Huntington's disease
Conditions
Interventions
The intervention is an exercise-based intervention with an aerobic component,
three times per week
for 12 weeks.
Sponsors
Cardiff University, Cardiff, UK
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) diagnosis of manifest HD, confirmed by genetic testing 2) above the age of 18 3) stable medication regime for four weeks prior to initiation of trial, and anticipated to be able to maintain a stable regime for the course of trial 4) enrolled in EHDN Registry study
Exclusion criteria
Exclusion criteria: 1) any physical or psychiatric condition that would prohibit the participant from completing the intervention or the full battery of assessments 2) inability to independently use the exercise bike 3) unable to understand or communicate in spoken English (UK sites only) 4) currently involved in any intervention trial or within four weeks of completing an intervention trial 5) current, regular participation in a structured exercise programme five times per week or more
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary aim of this study is to assess feasibility of the exercise intervention in terms of adherence, safety and process. This will be achieved through the documentation of adherence and any adverse events, as well as any health-related changes such as falls, hospital admissions, or healthcare service use that occur during the intervention period. Duration of participation and dropout from the intervention will also be recorded. In order to assess benefits, a range of outcomes that are representative of participation, activities and body functions, as defined by the World Health Organisation Classification of Functioning, Disability and Health, will be obtained. These will include measures of physical fitness, cognitive ability, and motor function. Standard clinical measures of disease severity and function as well as health-related quality of life will also be obtained. | — |
Secondary
| Measure | Time frame |
|---|---|
| - | — |
Countries
Netherlands
Outcome results
None listed