The association between coronary atherosclerosis and periodontitis: A clinical study

The association between coronary atherosclerosis and periodontitis: A clinical study - PaCmAn study: The link between Periodontitis and Coronary Atherosclerosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40327

Enrollment

Registered

2013-06-03

Start date

2013-03-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

parodontale aandoeningen atherosclerosis gum disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age 45-70 years Male and Female All ethnicities >= 10 teeth

Exclusion criteria

Exclusion criteria: Edentulous Known cardiovascular diseases Known Diabetes Mellitus Known autoimmune disorders Known immunosuppressive disorders

Design outcomes

Primary

Measure	Time frame
Inflammatory burden of periodontal disease will be quantified with the Periodontal Inflamed Surface Area (PISA) score.The endothelial function will be measured employing EndoScore using the ENDOPAT.	—

Secondary

Measure	Time frame
Reynolds risk score Framingham risk score Questionnaires: • Age • Sex • Ethnicity • Socio-economic status • Medical history and medication (history) • Parental history • Life-style (smoking, alcohol, drugs, stress) • Oral hygiene Physical examination: • Blood Pressure (BP) • Heart Rate (HR) • Body Mass Index (BMI) • Waist to Hip Ratio (WHR) • Electrocardiogram (ECG) Biochemical parameters: • High sensitive C-reactive Protein (hsCRP) • Total cholesterol • High Density Lipoprotein (HDL) cholesterol • Low Density Lipoprotein (LDL) cholesterol • Triglycerides • Estimated Glomerular Filtration Rate (eGFR) • Glycated Hemoglobine (HbA1c) Extra parameters for coupled studies: One blood sample for DNA analysis of risk genes for both periodontitis and coronary heart disease. Oral rinse sample for microbiological analysis of the oral microbiome peformed by pyrosequencing of 16Smicrobial DNA.	—

Measure

Time frame

Reynolds risk score Framingham risk score Questionnaires: • Age • Sex • Ethnicity • Socio-economic status • Medical history and medication (history) • Parental history • Life-style (smoking, alcohol, drugs, stress) • Oral hygiene Physical examination: • Blood Pressure (BP) • Heart Rate (HR) • Body Mass Index (BMI) • Waist to Hip Ratio (WHR) • Electrocardiogram (ECG) Biochemical parameters: • High sensitive C-reactive Protein (hsCRP) • Total cholesterol • High Density Lipoprotein (HDL) cholesterol • Low Density Lipoprotein (LDL) cholesterol • Triglycerides • Estimated Glomerular Filtration Rate (eGFR) • Glycated Hemoglobine (HbA1c) Extra parameters for coupled studies: One blood sample for DNA analysis of risk genes for both periodontitis and coronary heart disease. Oral rinse sample for microbiological analysis of the oral microbiome peformed by pyrosequencing of 16Smicrobial DNA.

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Countries

Netherlands

Outcome results