N/A
Conditions
Interventions
Muscle contractions inside the MR scanner will be used to disturb the metabolic
steady state of the tibialis anterior. Non-invasive 31P-MRs will be performed
before, during, and after these muscle c
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Potential volunteers must meet all of the following inclusion criteria: -healthy -male -young: between 18 to 35 years -BMI between 19 and 25 kg/m2 -MR compatibility is verified using a questionnnaire
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: -Epilepsy or medication against epilepsy -Subject is not MR compatible (e.g. because of pacemaker, claustrophobia, metal implants in the lower leg that may interfere with MRS, metal splinters in the eye)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main endpoint is the rate of PCr recovery after exercise for the different regions of the TA muscle. | — |
Secondary
| Measure | Time frame |
|---|---|
| The utilization of PCr, the buildup of inorganic phosphate, and the effect of exercise on pH during the muscle contractions are secondary endpoints. All these parameters can be obtained from the same MR spectrum can therefore be measured simultaneously. | — |
Countries
Netherlands
Outcome results
None listed