The immunological aspects of conventional therapy ((chemo)radiation) for the treatment of head and neck squamous cell carcinoma (HNSCC): an exploratory study.

The immunological aspects of conventional therapy ((chemo)radiation) for the treatment of head and neck squamous cell carcinoma (HNSCC): an exploratory study. - IMRAD

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON40292

Enrollment

Registered

2015-01-14

Start date

2015-04-14

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hoofd-hals plaveiselcelcarcinomen Head and neck cancer HPV+ head and neck squamous cell carcinoma (HNSCC)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Patients should be at least 18 years of age - Patients should be able and willing to provide informed consent - Patients should have the clinical diagnosis of HNSCC - Tumour should be HPV positive - WHO performance status 0-2 - Patients are scheduled for: 1.Primary external beam radiotherapy (EBRT) 2.Primary EBRT with concurrent chemotherapy (Cisplatin);

Exclusion criteria

Exclusion criteria: - Any medical condition that may interfere with the study objectives - Positive test result for HIV or Hepatitis B or C - Any other active malignancy than cervical cancer.

Design outcomes

Primary

Measure	Time frame
To monitor the systemic effects of radiotherapy (RT) alone or in combination with concurrent chemotherapy (CRT) (Cisplatin) on the immune response and T-cells over time in patients with head and neck squamous cell carcinoma (HNSCC). T-cell fenotypic changes and T-cell related functional changes will be investigated.	—

Secondary

Measure	Time frame
- To compare the systemic immunological effect of RT alone to CRT in HNSCC patients. - To determine the optimal timing for future vaccination in HNSCC patients	—

Countries

Netherlands

Outcome results