host defense Immune response
Conditions
Interventions
None listed
Sponsors
Sint Antonius Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Patients who participated in the Ovidius or Triple-P study (2004-2009). 2. Diagnosis in these studies with pneumococcal pneumonia or pneumonia due another identified organism. 3. Age * 18 years. 4. Signing of informed consent.
Exclusion criteria
Exclusion criteria: 1. Diagnosis of pneumonia without an identified causative organism. 2. Fever at time of vaccination. 3. Previous/known allergic reaction to any of the components of the vaccine given. 4. Mentally incompetent. 5. Previous pneumococcal vaccination. 6. Clinical pneumonia within 1 month prior to inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune response to pneumococcal vaccination in patients who were diagnosed with CAP due to S. pneumoniae in comparison with patients with another causative pathogen. Main parameters are antibody titres against the different pneumococcal serotypes before and after vaccination and avidity maturation of these antibodies. | — |
Secondary
| Measure | Time frame |
|---|---|
| * To investigate antibody response after pneumococcal vaccination in patients with community acquired pneumococcal pneumonia in the past who failed to elicit a specific antibody response previously. * To investigate the cellular immune responses after pneumococcal vaccination in patients with community acquired pneumococcal pneumonia in the past compared to pneumonia patients with another pathogen.. * To investigate quality of life by the RAND-36 score in patients with a community acquired pneumonia in the past. * To investigate the long-term mortality after community acquired pneumococcal pneumonia. | — |
Countries
Netherlands
Outcome results
None listed